Drug Name:Alfacalcidol
Drug Class:Vitamin D analogues
Mechanism of Action:
  • Alfacalcidol is a prodrug of calcitriol, the active form of vitamin D
  • It increases the absorption of calcium and phosphate from the gut
  • It also promotes bone mineralization
Use:
  • Treatment of vitamin D deficiency
  • Management of hypocalcemia and osteoporosis
  • Prevention of bone fractures in patients with osteoporosis
Side Effects:
  • Hypercalcemia
  • Hyperphosphatemia
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth
Contraindications:
  • Hypercalcemia
  • Hypersensitivity to alfacalcidol or vitamin D
  • Malabsorption syndrome
Specialty:
  • Endocrinology
  • Rheumatology
  • Geriatrics