Drug Name:Apraclonidine
Drug Class:Alpha-2 Adrenergic Agonist
Mechanism of Action:
  • Stimulates alpha-2 adrenergic receptors in the eye, reducing aqueous humor production and increasing uveoscleral outflow
  • May also reduce sympathetic tone in the eye, leading to decreased intraocular pressure
Use:
  • Treatment of open-angle glaucoma and ocular hypertension
Side Effects:
  • Ocular burning, stinging, or discomfort
  • Dry mouth
  • Headache
  • Dizziness
  • Fatigue
  • Hypotension
  • Bradycardia
Contraindications:
  • Hypersensitivity to apraclonidine or any component of the formulation
  • Use with MAO inhibitors or tricyclic antidepressants
  • Severe cardiovascular disease
Specialty:
  • Ophthalmology