| Drug Name: | Apremilast |
|---|
| Drug Class: | Phosphodiesterase-4 (PDE-4) inhibitor |
|---|
| Mechanism of Action: | Inhibits PDE-4, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP), which modulates inflammatory and immune responses |
|---|
| Use: | - Treatment of moderate to severe plaque psoriasis
- Treatment of active psoriatic arthritis
|
|---|
| Side Effects: | - Diarrhea
- Nausea
- Headache
- Upper respiratory tract infection
- Depression
- Weight loss
|
|---|
| Contraindications: | - Hypersensitivity to apremilast or any component of the formulation
- Severe renal impairment (eGFR less than 30 mL/min/1.73 m²)
|
|---|
| Specialty: | |
|---|