Drug Name:Ciclosporin
Drug Class:Immunosuppressant
Mechanism of Action:
  • Inhibits T-cell activation and proliferation by binding to cyclophilin
  • Prevents the production of interleukin-2 and other cytokines
Use:
  • Prevention of organ rejection in transplant patients
  • Treatment of autoimmune diseases such as psoriasis, rheumatoid arthritis, and lupus
Side Effects:
  • Nephrotoxicity
  • Hypertension
  • Hyperlipidemia
  • Tremors
  • Gingival hyperplasia
Contraindications:
  • Hypersensitivity to ciclosporin or its components
  • Uncontrolled hypertension
  • Uncontrolled infections
Specialty:
  • Transplant medicine
  • Rheumatology
  • Dermatology