Drug Name:Clomiphene
Drug Class:Selective Estrogen Receptor Modulator (SERM)
Mechanism of Action:
  • Blocks estrogen receptors in the hypothalamus
  • Increases release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
Use:
  • Treatment of infertility in women with anovulation
  • Stimulation of ovulation in women with polycystic ovary syndrome (PCOS)
Side Effects:
  • Hot flashes
  • Abdominal discomfort
  • Breast tenderness
  • Nausea
  • Headache
Contraindications:
  • Pregnancy
  • Liver disease
  • Abnormal uterine bleeding
  • Ovarian cysts
Specialty:
  • Obstetrics and Gynecology
  • Reproductive Endocrinology