Drug Name: | Colchicine |
---|
Drug Class: | Anti-gout agent |
---|
Mechanism of Action: | - Binds to tubulin, inhibiting microtubule formation and preventing leukocyte migration and phagocytosis
- Inhibits the release of inflammatory cytokines
|
---|
Use: | - Treatment and prevention of gout flares
- Treatment of familial Mediterranean fever
|
---|
Side Effects: | - Nausea, vomiting, diarrhea
- Abdominal pain
- Myelosuppression
- Myopathy
- Peripheral neuropathy
|
---|
Contraindications: | - Hypersensitivity to colchicine
- Severe renal or hepatic impairment
- Concomitant use with strong CYP3A4 inhibitors or P-gp inhibitors
|
---|
Specialty: | - Rheumatology
- Internal Medicine
|
---|