Drug Name:Crizanlizumab
Drug Class:Monoclonal antibody
Mechanism of Action:
  • Binds to P-selectin, preventing platelet-endothelial cell adhesion and subsequent vaso-occlusion
Use:
  • Prevention of vaso-occlusive crises in patients with sickle cell disease
Side Effects:
  • Nausea
  • Back pain
  • Fever
  • Arthralgia
  • Diarrhea
  • Abdominal pain
Contraindications:
  • None known
Specialty:
  • Hematology
  • Oncology