Drug Name:Dabigatran
Drug Class:Direct oral anticoagulant (DOAC)
Mechanism of Action:
  • Inhibits thrombin, a key enzyme in the coagulation cascade
Use:
  • Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
  • Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)
Side Effects:
  • Bleeding (most common)
  • Gastrointestinal symptoms (nausea, dyspepsia, abdominal pain)
  • Headache
  • Increased risk of myocardial infarction (MI) in patients with a history of MI
Contraindications:
  • Active bleeding
  • Severe renal impairment (CrCl < 30 mL/min)
  • Mechanical heart valve
  • Hypersensitivity to dabigatran or any component of the formulation
Specialty:
  • Cardiology
  • Hematology
  • Internal Medicine