Drug Name: | Disulfiram |
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Drug Class: | Alcohol deterrent |
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Mechanism of Action: | - Inhibits aldehyde dehydrogenase, leading to accumulation of acetaldehyde
- Acetaldehyde accumulation causes unpleasant symptoms when alcohol is consumed
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Use: | - Adjunctive treatment of alcohol dependence
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Side Effects: | - Nausea
- Vomiting
- Headache
- Dizziness
- Metallic or garlic-like taste in mouth
- Drowsiness
- Fatigue
- Impotence
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Contraindications: | - Severe myocardial disease
- Psychosis
- Severe renal impairment
- Hypersensitivity to disulfiram or thiuram derivatives
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Specialty: | - Addiction medicine
- Psychiatry
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