Drug Name:Duloxetine
Drug Class:Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Mechanism of Action:
  • Inhibits the reuptake of serotonin and norepinephrine in the brain
  • Modulates pain perception in the central nervous system
Use:
  • Major depressive disorder
  • Generalized anxiety disorder
  • Diabetic peripheral neuropathic pain
  • Fibromyalgia
  • Chronic musculoskeletal pain
Side Effects:
  • Nausea
  • Dry mouth
  • Constipation
  • Insomnia
  • Dizziness
  • Fatigue
  • Sweating
  • Decreased appetite
  • Sexual dysfunction
Contraindications:
  • Hypersensitivity to duloxetine
  • Concurrent use of monoamine oxidase inhibitors (MAOIs)
  • Severe hepatic impairment
  • Uncontrolled narrow-angle glaucoma
Specialty:
  • Psychiatry
  • Neurology
  • Pain management