Drug Name: | Etidronate |
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Drug Class: | Bisphosphonate |
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Mechanism of Action: | - Inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite crystals in bone
- Inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway, which is essential for osteoclast function
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Use: | - Treatment of Paget's disease of bone
- Prevention and treatment of osteoporosis
- Hypercalcemia of malignancy
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Side Effects: | - Gastrointestinal upset
- Headache
- Musculoskeletal pain
- Hypocalcemia
- Osteonecrosis of the jaw
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Contraindications: | - Hypersensitivity to etidronate
- Severe renal impairment
- Hypocalcemia
- Pregnancy and breastfeeding
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Specialty: | - Rheumatology
- Endocrinology
- Oncology
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