| Drug Name: | Itraconazole |
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| Drug Class: | Antifungal |
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| Mechanism of Action: | - Inhibits fungal cytochrome P450-dependent enzymes, leading to inhibition of ergosterol synthesis and disruption of fungal cell membrane integrity
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| Use: | - Treatment of systemic fungal infections such as aspergillosis, blastomycosis, histoplasmosis, and candidiasis
- Treatment of onychomycosis (fungal nail infection)
- Prophylaxis of fungal infections in immunocompromised patients
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| Side Effects: | - Nausea, vomiting, diarrhea
- Headache, dizziness
- Rash, itching
- Liver toxicity
- Heart failure (rare)
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| Contraindications: | - Hypersensitivity to itraconazole or other azole antifungals
- Concomitant use with certain medications such as cisapride, dofetilide, pimozide, quinidine, and ergot alkaloids
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| Specialty: | - Infectious disease
- Dermatology
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