Drug Name: | Ivabradine |
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Drug Class: | Cardiovascular agent |
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Mechanism of Action: | - Inhibits the If current in the sinoatrial node, reducing heart rate without affecting contractility or conduction
- Reduces myocardial oxygen demand
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Use: | - Treatment of stable angina pectoris in patients with normal sinus rhythm who have a contraindication or intolerance to beta-blockers
- Treatment of chronic heart failure with reduced ejection fraction in patients with sinus rhythm and a heart rate of 70 bpm or higher
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Side Effects: | - Bradycardia
- Phosphenes (visual disturbances)
- Atrial fibrillation
- Hypotension
- Headache
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Contraindications: | - Acute myocardial infarction
- Sick sinus syndrome
- Severe hypotension
- Severe hepatic impairment
- Concomitant use of strong CYP3A4 inhibitors
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Specialty: | - Cardiology
- Internal medicine
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