Drug Name: | Levomepromazine |
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Drug Class: | Phenothiazine antipsychotic |
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Mechanism of Action: | - Blocks dopamine and serotonin receptors in the brain
- Also has antihistamine and anticholinergic effects
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Use: | - Treatment of schizophrenia and other psychotic disorders
- Management of severe nausea and vomiting
- Adjunctive therapy for severe pain
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Side Effects: | - Sedation
- Orthostatic hypotension
- Anticholinergic effects (dry mouth, blurred vision, constipation, urinary retention)
- Extrapyramidal symptoms (tremors, rigidity, akathisia, tardive dyskinesia)
- Increased risk of seizures
- Photosensitivity
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Contraindications: | - Hypersensitivity to levomepromazine or other phenothiazines
- Comatose states
- CNS depression
- Severe hypotension
- Severe liver or kidney disease
- Blood dyscrasias
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Specialty: | - Psychiatry
- Oncology
- Palliative care
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