Drug Name:Linezolid
Drug Class:Oxazolidinone Antibiotic
Mechanism of Action:
  • Inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit, preventing the formation of the initiation complex
Use:
  • Treatment of infections caused by Gram-positive bacteria, including MRSA, VRE, and Streptococcus pneumoniae
Side Effects:
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Insomnia
  • Peripheral neuropathy
  • Thrombocytopenia
  • Serotonin syndrome (rare)
Contraindications:
  • Hypersensitivity to linezolid or any component of the formulation
  • Concurrent use of MAO inhibitors
  • Uncontrolled hypertension
  • Pheochromocytoma
  • Thyroid cancer
  • Use in neonates and infants with hyperbilirubinemia
Specialty:
  • Infectious Disease
  • Critical Care
  • Pulmonology