Drug Name:Methotrexate
Drug Class:Antimetabolite
Mechanism of Action:
  • Inhibits dihydrofolate reductase, leading to decreased DNA synthesis and cell proliferation
Use:
  • Treats cancer (leukemia, lymphoma, breast cancer, lung cancer)
  • Treats autoimmune diseases (rheumatoid arthritis, psoriasis, Crohn's disease)
Side Effects:
  • Nausea, vomiting, diarrhea
  • Mouth sores
  • Hair loss
  • Liver damage
  • Bone marrow suppression
  • Increased risk of infection
  • Pulmonary toxicity
Contraindications:
  • Pregnancy
  • Breastfeeding
  • Liver disease
  • Kidney disease
  • Immunodeficiency
  • Alcoholism
Specialty:
  • Oncology
  • Rheumatology
  • Dermatology
  • Gastroenterology