Drug Name: | Methyldopa |
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Drug Class: | Central alpha-2 agonist |
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Mechanism of Action: | Stimulates alpha-2 receptors in the brainstem, reducing sympathetic outflow and decreasing peripheral vascular resistance |
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Use: | - First-line treatment for hypertension in pregnancy
- May also be used for gestational hypertension and preeclampsia
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Side Effects: | - Sedation
- Dry mouth
- Headache
- Depression
- Hepatitis
- Hemolytic anemia
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Contraindications: | - Active liver disease
- History of depression
- Concurrent use of MAO inhibitors
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Specialty: | - Obstetrics
- Maternal-Fetal Medicine
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