| Drug Name: | Metoclopramide |
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| Drug Class: | Dopamine antagonist |
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| Mechanism of Action: | - Blocks dopamine receptors in the chemoreceptor trigger zone and in the GI tract
- Increases motility of the upper GI tract
- Increases tone of the lower esophageal sphincter
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| Use: | - Treatment of nausea and vomiting
- Management of gastroparesis
- Facilitation of small bowel intubation
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| Side Effects: | - Extrapyramidal symptoms (dystonia, akathisia, tardive dyskinesia)
- Sedation
- Diarrhea
- Hyperprolactinemia
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| Contraindications: | - GI obstruction or perforation
- Pheochromocytoma
- Parkinson's disease
- Epilepsy
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| Specialty: | - Gastroenterology
- Emergency Medicine
- Internal Medicine
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