Drug Name:Paroxetine
Drug Class:Selective Serotonin Reuptake Inhibitor (SSRI)
Mechanism of Action:
  • Inhibits the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synaptic cleft
Use:
  • Major depressive disorder
  • Obsessive-compulsive disorder
  • Panic disorder
  • Social anxiety disorder
  • Generalized anxiety disorder
  • Post-traumatic stress disorder
  • Premenstrual dysphoric disorder
Side Effects:
  • Nausea
  • Dry mouth
  • Headache
  • Insomnia
  • Drowsiness
  • Dizziness
  • Sweating
  • Tremors
  • Sexual dysfunction
  • Weight gain
Contraindications:
  • Hypersensitivity to paroxetine
  • Concomitant use with monoamine oxidase inhibitors (MAOIs)
  • Concomitant use with thioridazine
  • Severe hepatic impairment
Specialty:
  • Psychiatry
  • Primary care