Drug Name: | Pentoxyphylline |
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Drug Class: | Methylxanthine derivative |
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Mechanism of Action: | - Inhibits phosphodiesterase
- Increases cAMP levels
- Inhibits TNF-alpha production
- Improves erythrocyte flexibility
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Use: | - Peripheral vascular disease
- Intermittent claudication
- Cerebrovascular insufficiency
- Chronic venous insufficiency
- Diabetic neuropathy
- Acute respiratory distress syndrome
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Side Effects: | - Nausea
- Vomiting
- Headache
- Dizziness
- Tachycardia
- Hypotension
- Bleeding
- Hypersensitivity reactions
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Contraindications: | - Hypersensitivity to pentoxyphylline
- Recent cerebral and/or retinal hemorrhage
- Severe bleeding disorders
- Pregnancy and lactation
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Specialty: | - Cardiology
- Neurology
- Vascular medicine
- Pulmonology
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