Drug Name:Pentoxyphylline
Drug Class:Methylxanthine derivative
Mechanism of Action:
  • Inhibits phosphodiesterase
  • Increases cAMP levels
  • Inhibits TNF-alpha production
  • Improves erythrocyte flexibility
Use:
  • Peripheral vascular disease
  • Intermittent claudication
  • Cerebrovascular insufficiency
  • Chronic venous insufficiency
  • Diabetic neuropathy
  • Acute respiratory distress syndrome
Side Effects:
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Tachycardia
  • Hypotension
  • Bleeding
  • Hypersensitivity reactions
Contraindications:
  • Hypersensitivity to pentoxyphylline
  • Recent cerebral and/or retinal hemorrhage
  • Severe bleeding disorders
  • Pregnancy and lactation
Specialty:
  • Cardiology
  • Neurology
  • Vascular medicine
  • Pulmonology