Drug Name: | Phenobarbital |
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Drug Class: | Barbiturate |
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Mechanism of Action: | - Enhances the activity of GABA, an inhibitory neurotransmitter, by binding to GABA-A receptors in the brain
- Reduces the excitability of neurons in the brainstem and cortex
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Use: | - Treatment of seizures (partial, generalized, tonic-clonic)
- Sedation
- Insomnia
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Side Effects: | - Drowsiness
- Dizziness
- Ataxia
- Nausea
- Vomiting
- Confusion
- Depression
- Respiratory depression
- Hypotension
- Bradycardia
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Contraindications: | - Hypersensitivity to barbiturates
- Porphyria
- Respiratory depression
- Severe liver disease
- Pregnancy
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Specialty: | - Neurology
- Psychiatry
- Emergency Medicine
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