Drug Name:Piperacillin-Tazobactam
Drug Class:Antibiotic
Mechanism of Action:
  • Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
  • Tazobactam inhibits bacterial beta-lactamases, which can break down piperacillin
Use:
  • Treatment of moderate to severe infections caused by susceptible gram-negative and gram-positive bacteria
  • Commonly used for intra-abdominal infections, skin and soft tissue infections, and pneumonia
Side Effects:
  • Nausea, vomiting, diarrhea
  • Headache, dizziness
  • Rash, itching
  • Hypersensitivity reactions
  • Increased risk of Clostridium difficile infection
Contraindications:
  • Hypersensitivity to penicillins or beta-lactam antibiotics
  • History of severe allergic reactions to any beta-lactam antibiotic
Specialty:
  • Infectious Disease
  • Critical Care
  • Emergency Medicine