Drug Name:Promethazine
Drug Class:Antihistamine, Antiemetic, Sedative
Mechanism of Action:Blocks histamine H1 receptors, antagonizes dopamine D2 receptors, and has anticholinergic properties
Use:
  • Relief of allergic symptoms such as itching, runny nose, and sneezing
  • Prevention and treatment of nausea and vomiting
  • Sedation and relief of anxiety
Side Effects:
  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Confusion
  • Tremors
  • Seizures (rare)
Contraindications:
  • Hypersensitivity to promethazine or any of its components
  • Comatose states
  • Severe respiratory depression
  • Narrow-angle glaucoma
  • Pyloroduodenal obstruction
  • Stenosing peptic ulcer
  • Bladder neck obstruction
  • Bone marrow depression
  • Reye's syndrome
Specialty:
  • Allergy and Immunology
  • Emergency Medicine
  • Gastroenterology
  • Internal Medicine
  • Neurology
  • Oncology
  • Pediatrics
  • Psychiatry