Drug Name:Pyridostigmine
Drug Class:Acetylcholinesterase inhibitor
Mechanism of Action:
  • Inhibits the breakdown of acetylcholine by acetylcholinesterase, leading to increased levels of acetylcholine in the synaptic cleft
  • Enhances neuromuscular transmission and improves muscle strength
Use:
  • Myasthenia gravis
  • Reversal of neuromuscular blockade
Side Effects:
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Excessive salivation
  • Sweating
  • Miosis
  • Bradycardia
  • Hypotension
  • Muscle cramps
  • Weakness
Contraindications:
  • Hypersensitivity to pyridostigmine or other cholinesterase inhibitors
  • Mechanical obstruction of the gastrointestinal or urinary tract
  • Bradycardia
  • Intestinal or urinary tract obstruction
  • Asthma
  • Epilepsy
  • Parkinson's disease
Specialty:
  • Neurology
  • Anesthesiology