| Drug Name: | Quinine |
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| Drug Class: | Antimalarial |
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| Mechanism of Action: | - Inhibits heme polymerase enzyme in the parasite, preventing the conversion of heme to hemozoin, leading to the accumulation of toxic heme in the parasite
- Interferes with the parasite's ability to digest hemoglobin
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| Use: | - Treatment of uncomplicated malaria caused by Plasmodium falciparum
- Prophylaxis of malaria in areas with chloroquine-resistant strains
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| Side Effects: | - Cinchonism (headache, tinnitus, vertigo, nausea, vomiting, diarrhea)
- Hypersensitivity reactions
- Cardiotoxicity (QT prolongation, arrhythmias)
- Hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency
- Thrombocytopenia
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| Contraindications: | - Hypersensitivity to quinine or quinidine
- History of blackwater fever
- Myasthenia gravis
- Pregnancy (except for treatment of severe malaria)
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| Specialty: | - Infectious Disease
- Tropical Medicine
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