Drug Name: | Raloxifene |
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Drug Class: | Selective estrogen receptor modulator (SERM) |
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Mechanism of Action: | - Binds to estrogen receptors and modulates their activity in different tissues
- Agonist in bone and antagonist in breast and uterus
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Use: | - Prevention and treatment of osteoporosis in postmenopausal women
- Reduction of risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer
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Side Effects: | - Hot flashes
- Leg cramps
- Increased risk of venous thromboembolism
- Increased risk of stroke
- Increased risk of death from stroke in women with pre-existing coronary heart disease
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Contraindications: | - Pregnancy and lactation
- History of venous thromboembolism
- History of stroke or transient ischemic attack
- Severe liver disease
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Specialty: | - Endocrinology
- Obstetrics and Gynecology
- Rheumatology
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