| Drug Name: | Sacubitril |
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| Drug Class: | Neprilysin inhibitor |
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| Mechanism of Action: | Inhibits neprilysin, an enzyme responsible for the degradation of natriuretic peptides, leading to increased levels of natriuretic peptides which promote vasodilation and diuresis |
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| Use: | - Treatment of heart failure with reduced ejection fraction (HFrEF)
- Reduces the risk of cardiovascular death and hospitalization for heart failure
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| Side Effects: | - Hypotension
- Hyperkalemia
- Angioedema
- Renal impairment
- Cough
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| Contraindications: | - History of angioedema related to previous ACE inhibitor or ARB use
- Concomitant use with ACE inhibitors
- Concomitant use with aliskiren in patients with diabetes
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| Specialty: | - Cardiology
- Internal Medicine
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