Drug Name:Sumatriptan
Drug Class:Serotonin receptor agonist
Mechanism of Action:
  • Selective agonist for 5-HT1B/1D receptors in cranial arteries
  • Inhibits release of vasoactive peptides
  • Reduces inflammation and pain transmission
Use:
  • Acute treatment of migraine attacks with or without aura
  • Cluster headache
Side Effects:
  • Chest discomfort
  • Dizziness
  • Fatigue
  • Nausea
  • Injection site reactions
Contraindications:
  • Ischemic heart disease
  • Uncontrolled hypertension
  • History of stroke or TIA
  • Peripheral vascular disease
  • Severe hepatic impairment
Specialty:
  • Neurology
  • Emergency Medicine
  • Primary Care