Drug Name:Tacrolimus
Drug Class:Immunosuppressant
Mechanism of Action:
  • Binds to FK-binding protein-12 (FKBP-12), inhibiting calcineurin phosphatase activity
  • Prevents the activation of T-cells and the production of cytokines
Use:
  • Prevention of organ rejection in transplant patients
  • Treatment of atopic dermatitis
Side Effects:
  • Nephrotoxicity
  • Neurotoxicity
  • Hypertension
  • Hyperglycemia
  • Tremors
  • Headache
Contraindications:
  • Hypersensitivity to tacrolimus or any component of the formulation
  • Concurrent use with strong CYP3A4 inhibitors or inducers
Specialty:
  • Transplant medicine
  • Dermatology