Drug Name: | Tacrolimus |
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Drug Class: | Immunosuppressant |
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Mechanism of Action: | - Binds to FK-binding protein-12 (FKBP-12), inhibiting calcineurin phosphatase activity
- Prevents the activation of T-cells and the production of cytokines
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Use: | - Prevention of organ rejection in transplant patients
- Treatment of atopic dermatitis
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Side Effects: | - Nephrotoxicity
- Neurotoxicity
- Hypertension
- Hyperglycemia
- Tremors
- Headache
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Contraindications: | - Hypersensitivity to tacrolimus or any component of the formulation
- Concurrent use with strong CYP3A4 inhibitors or inducers
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Specialty: | - Transplant medicine
- Dermatology
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