Drug Name: | Tetrabenazine |
---|
Drug Class: | Vesicular monoamine transporter 2 (VMAT2) inhibitor |
---|
Mechanism of Action: | - Inhibits the uptake of monoamines (dopamine, norepinephrine, serotonin) into synaptic vesicles, leading to a decrease in their release
- Reduces the amount of dopamine available for release in the striatum, which helps to control involuntary movements
|
---|
Use: | - Treatment of chorea associated with Huntington's disease
- Treatment of tardive dyskinesia
|
---|
Side Effects: | - Depression
- Somnolence
- Parkinsonism
- Akathisia
- Restlessness
- Insomnia
- Nausea
- Vomiting
- Diarrhea
- Dry mouth
- Fatigue
- Anxiety
- Agitation
- Suicidal ideation
|
---|
Contraindications: | - Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Concomitant use with reserpine
- History of depression or suicidal ideation
- Hypersensitivity to tetrabenazine or any component of the formulation
|
---|
Specialty: | |
---|