Drug Name:Trazodone
Drug Class:Serotonin antagonist and reuptake inhibitor (SARI)
Mechanism of Action:
  • Blocks serotonin 5-HT2A receptors
  • Inhibits serotonin reuptake
Use:
  • Treatment of major depressive disorder
  • Insomnia
Side Effects:
  • Drowsiness
  • Dry mouth
  • Dizziness
  • Headache
  • Nausea
  • Constipation
  • Blurred vision
  • Priapism (rare)
Contraindications:
  • Hypersensitivity to trazodone
  • Concomitant use with MAO inhibitors
  • Acute recovery phase following myocardial infarction
Specialty:
  • Psychiatry
  • Sleep medicine