| Drug Name: | Zoledronate |
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| Drug Class: | Bisphosphonate |
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| Mechanism of Action: | - Inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite crystals in bone
- Inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway
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| Use: | - Treatment of osteoporosis in postmenopausal women
- Treatment of Paget's disease of bone
- Prevention of skeletal-related events in patients with bone metastases from solid tumors
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| Side Effects: | - Flu-like symptoms (fever, fatigue, myalgia)
- Nausea, vomiting, diarrhea
- Hypocalcemia
- Renal impairment
- Osteonecrosis of the jaw
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| Contraindications: | - Hypersensitivity to bisphosphonates
- Severe renal impairment
- Pregnancy and breastfeeding
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| Specialty: | - Endocrinology
- Oncology
- Rheumatology
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